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- 2018
IL-24在口腔鳞状细胞癌中的表达及其临床意义
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Abstract:
摘要 目的:研究白细胞介素-24 (IL-24)在口腔鳞状细胞癌(简称鳞癌)组织中的表达并探究其临床意义。方法:分别采用免疫组化和实时聚合酶链反应(Real-time PCR)技术的方法检测75例口腔鳞癌组织和30例正常口腔黏膜组织中IL-24的蛋白和基因表达。结果:免疫组化染色显示IL-24在口腔鳞癌组织中的阳性表达率45.33%(34/75)低于正常口腔黏膜组织中的阳性表达率70.00%(21/30)(P=0.022)。IL-24的表达与口腔鳞癌的组织分化程度(P=0.002),淋巴结转移(P=0.033),临床分期(P=0.035)有密切相关性,与患者的性别(P=0.917)、年龄(P=0.812)、吸烟史(P=0.720)、饮酒史(P=0.847)及肿瘤生长部位(P=0.959)无相关性。Real-time PCR检测IL-24在不同病理分化时期口腔鳞癌组织和正常口腔黏膜组织中的基因表达水平,其高、中、低分化各组的平均表达水平分别为0.688、0.302、0.153,均低于正常口腔黏膜组织中的平均表达水平1.000(P<0.001)。结论:IL-24在口腔鳞癌组织中呈低表达,该因子的表达情况与临床信息具有一定相关性,可初步认定为口腔鳞癌的候补抑癌基因
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