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- 2017
利用潮汕人群第一前磨牙牙本质天冬氨酸消旋化比率推断生物学年龄的研究
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Abstract:
摘要 目的:探讨潮汕人群第一前磨牙牙本质天冬氨酸消旋化比率推断年龄的准确性。方法:收集潮汕人群第一前磨牙标本60例,利用高效液相色谱法检测其牙本质内天冬氨酸消旋化(D/L)比率,并与实际年龄建立回归方程;再用3例另外收集的牙本质标本检验方程的准确性。结果:潮汕人群第一前磨牙牙本质天冬氨酸消旋化(D/L)比率与年龄高度正相关(P<0.001),相关系数r=0.967,消旋化速率k=6.0×10-4/年,推断年龄误差SE=2.60岁。3例验证标本的误差分别是-0.3岁,+1.6岁,-2.2岁。结论:潮汕人群第一前磨牙牙本质天冬氨酸消旋化(D/L)比率可以准确推断年龄
[1] | Ohtani S, Ito R, Yamamoto T. Differences in the D/L aspartic acid ratios in dentin among different types of teeth from the same individual and estimated age [J]. Int J Legal Med. 2003, 117(3)∶149-152 |
[2] | Meissner C, Ritz-Timme S. Molecular pathology and age estimation [J]. Forensic Sci Int, 2010, 203(1-3)∶34-43 |
[3] | Li XY, Su M, Huang HH, et al. mtDNA evidence: genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China [J]. Genomics, 2007, 90(4)∶474-81 |
[4] | Chen S, Lv Y, Wang D, Yu X. Aspartic acid racemization in dentin of the third molar for age estimation of the Chaoshan population in South China [J]. Forensic Sci Int, 2016, 266(2)∶234-238 |
[5] | Ohtani S, Yamamoto T. Strategy for the estimation of chronological age using the aspartic acid racemization method with special reference to coefficient of correlation between D/L ratios and ages [J]. J Forensic Sci, 2005, 50(1)∶1-8 |
[6] | Fu SJ, Fan CC, Song HW, et al. Age estimation using a modified HPLC determination of ratio of aspartic acid in dentin [J]. Forensic Sci Int, 1995, 73(1)∶35-40 |
[7] | Kastle M, Grune T. Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system [J]. Curr Pharm Des, 2011, 17(36)∶4007-4022 |
[8] | Yekkala R, Meers C, Van Schepdael A, et al. Racemization of aspartic acid from human dentin in the estimation of chronological age [J]. Forensic Sci Int, 2006,159(1)∶S89-S94 |
[9] | Kvaal SI, Kolltveit KM, Thomsen IO, et al. Age estimation of adults from dental radiographs [J]. Forensic Sci Int, 1995, 74(3)∶175-185 |
[10] | Rajkumari S, Nirmal M, Sunil PM, et al. Estimation of age using aspartic acid racemisation in human dentin in Indian population [J]. Forensic Sci Int, 2013, 228(1-3)∶38-41 |
[11] | Ohtani S. Different racemization ratios in dentin from different locations within a tooth [J]. Growth Dev Aging, 1997, 61(2)∶93-99 |