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- 2015
乙醇浴“一步交联”法制备明胶三维大孔纳米纤维支架
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Abstract:
摘要 目的:探讨采用乙醇浴“一步交联”法制备静电纺丝水溶性大分子纤维支架。方法:分别采用乙醇浴“一步交联”法和“二步交联”法制备明胶静电纺丝纤维,分析两种方法对纤维形貌、结构、交联度及稳定性的影响。结果:与“二步交联”纤维相比,“一步交联”法收集的明胶纤维直径更细,孔隙更大,吸水率更高,能维持纤维及支架的结构。通过对交联剂浓度及交联时间进行调整,可以改变纤维的交联度。“一步交联”纤维已具有良好的稳定性,无需再进行交联处理。结论:乙醇浴“一步交联”技术能有效维持明胶纤维的形貌及结构,提高交联效率,制备出较理想的三维大孔纳米支架
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