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- 2015
新疆木垒县哈萨克族慢性牙周炎患者血清与唾液中IL-6、IL-17的表达及相关性分析
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Abstract:
摘要 目的:研究哈萨克族慢性牙周炎(chronic periodontitis,CP)患者血清和唾液中白细胞介素17(interleukin 17, IL17 )、白细胞介素6(interleukin 6, IL6 ) 的活性表达及相关性分析。方法:选择哈萨克族慢性牙周炎患者192例,健康人100例,记录临床牙周检查指标,采集非刺激性全唾液及外周血液各5 mL。采用抗体夹心ELISA法测定CP患者与健康人群唾液及血液中IL-17、IL-6总量和浓度。结果:牙周炎患者的唾液IL-6、IL-17浓度要显著高于血清IL-6、IL-17。在唾液中IL-6与IL-17彼此呈中度正相关性,且二者与牙周临床指标均为高度正相关关系。结论:唾液IL-6、IL-17在哈萨克族慢性牙周炎患者的表达水平明显增高,且与病情严重程度相关,可作为萨克族慢性牙周炎患者的诊断标志物,对二者的相关性可从基因学方面进行下一步研究
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