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- 2017
新疆维吾尔族儿童龋病与HLA-DRB1等位基因多态性的相关性研究
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Abstract:
摘要 目的:探讨人类白细胞抗原(human leucocyte antigen,HLA) -DRB1等位基因多态性与新疆维吾尔族儿童龋病的相关性。方法:采用聚合酶链式反应-序列特异性引物(polymerase chain reaction-sequence specific primer, PCR-SSP)DNA分型技术对40例新疆维吾尔族高龋儿童和40例新疆维吾尔族健康对照儿童进行HLA-DRB1基因分型,研究HLA-DRB1基因多态性与新疆维吾尔族儿童龋病的相关性。结果:高龋组与对照组在HLA-DRB1座位共检出13个特异性基因位点。两组等位基因频率分布有相同之处,均表现为HLA-DRB1* 01基因表达最高(≥47.5%),HLA-DRB1* 08和*09基因表达最低(≤12.5%);高龋组中HLA-DRB1* 11和*13等位基因频率(分别为40.0%和47.5%)显著高于对照组(分别为17.5%和17.5%),差异均有统计学意义(P＜0.05,OR值分别为3.143和3.619);而HLA-DRB1* 04和*07等位基因频率(分别为15.0%和17.5%)显著低于对照组(分别为37.5%和50.0%),差异均有统计学意义(P＜0.05,OR值分别为0.294和0.212)。结论:新疆维吾尔族儿童龋病与HLA-DRB1等位基因多态性具有一定的相关性;HLA-DRB1* 11和*13等位基因可能是该人群的龋病易感基因,HLA-DRB1* 04和*07等位基因可能是该人群的龋病保护基因
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