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- 2017
消退素D1治疗实验性大鼠牙周炎的研究
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Abstract:
摘要 目的: 探讨消退素D1(RvD1)对治疗牙周炎的作用。方法: 取18只大鼠建立牙周炎模型,按随机化原则均分为实验甲组(100 μg/L的RvD1),实验乙组(50 μg/L的 RvD1)及阴性对照丙组(生理盐水)。所有大鼠均经尾静脉注射给药进行治疗。治疗后不同时间进行临床检查和形态学测量。采用SPSS21.0软件包对数据进行单因素方差分析。结果: 治疗后,实验甲组(100 μg/L RvD1)中牙周袋深度、牙龈指数、松动度、牙槽骨丧失量均低于阴性对照组(P<0.05)。实验乙组(50 μg/L RvD1)的以上4个指标虽均低于阴性对照组,但仅牙龈指数和松动度与阴性对照组的差异有统计学意义(P<0.05)。两实验组治疗后的牙周袋深度相近(P>0.05)。结论: 两种浓度的RvD1对实验性大鼠牙周炎有治疗作用;100 μg/L的RvD1可阻止实验性大鼠牙周炎的牙槽骨继续破坏
| [1] | Mustafa M, Zarrough A, Bolstad AI, et al. Resolvin D1 protects periodontal ligament [J]. American journal of physiology Cell physiology,2013,305(6)∶C673-679 |
| [2] | Steffens JP, Herrera BS, Coimbra LS, et al. Testosterone regulates bone response to inflammation [J]. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,2014,46(3)∶193-200 |
| [3] | 刘飞,张林,肖刚,等.生命早期负性应激对大鼠实验性牙周炎的影响[J].口腔医学研究,2017,33(3)∶244-248 |
| [4] | Cianci E, Recchiuti A, Trubiani O, et al. Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins [J]. STEM CELLS Translational Medicine,2016,5(1)∶20-32 |
| [5] | Maekawa T, Hosur K, Abe T, et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3beta-C/EBPbeta pathway [J]. Nature communications,2015,6∶8272 |
| [6] | Fredman G, Oh SF, Ayilavarapu S, et al. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1 [J]. PloS one,2011,6(9)∶e24422 |
| [7] | Fredman G, Serhan CN. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution [J]. The Biochemical journal,2011,437(2)∶185-197 |
| [8] | Lee CT, Teles R, Kantarci A, et al. Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis [J]. Journal of immunology,2016,197(7)∶2796-806 |
| [9] | Schwab JM, Chiang N, Arita M, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes [J]. Nature,2007,447(7146)∶869-874 |
| [10] | Kohli P, Levy BD. Resolvins and protectins: mediating solutions to inflammation [J]. British journal of pharmacology,2009,158(4)∶960-971 |
| [11] | Damgaard C, Kantarci A, Holmstrup P, et al. Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-alpha, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1 [J]. Journal of periodontal research,2017,52(2)∶246-254 |
