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- 2018
箭根酮对LPS刺激牙周膜成纤维细胞增殖能力的影响
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Abstract:
摘要 目的:研究箭根酮对LPS刺激牙周膜成纤维细胞增殖能力的影响及机制研究。方法:将人牙周膜成纤维细胞培养在含LPS的培养液中,同时加入或不加不同浓度的箭根酮,同时设不含箭根酮的空白对照组,24、48、72 h 后,以CCK-8 法检测细胞的增殖情况。流式检测细胞凋亡情况。结果:加药培养24、48、72 h后,不同浓度箭根酮组细胞的相对活性明显低于对照组和LPS刺激组,结果有统计学意义(P<0.001)。流式结果表明,相比于对照组,箭根酮能够显著促进细胞凋亡。结论:箭根酮对LPS刺激的牙周膜成纤维细胞增殖具有明显抑制作用,且其可能机制为促进细胞凋亡
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