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- 2017
PTEN对H2O2诱导的牙周膜细胞增殖凋亡的影响
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Abstract:
摘要 目的:探讨第10号染色体同源缺失性磷酸酶-张力蛋白(PTEN)对过氧化氢(H2O2)诱导的牙周膜细胞增殖凋亡的影响。方法:分离培养人牙周膜细胞,转染PTEN小干扰RNA、小干扰RNA阴性对照,H2O2处理,Western blot检测PTEN表达水平。结果:人牙周膜细胞转染PTEN小干扰RNA后的细胞中PTEN表达受到抑制。结论:干扰PTEN表达能够拮抗 H2O2诱导的人牙周膜细胞凋亡及人牙周膜细胞增殖抑制作用
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