Dy GW,Gore JL,Forouzanfar MH,et al.Global Burden of Urologic Cancers,1990-2013[J].Eur Urol,2017,71(3):437-446.
[2]
Hu Y,Zhou J,Ye F,et al.BRD4inhibitor inhibits colorectal cancer growth and metastasis[J].Int J Mol Sci,2015,16(1):1 928-1 948.
[3]
Kanno T,Kanno Y,LeRoy G,et al.BRD4assists elongation of both coding and enhancer RNAs by interacting with acetylated histones[J].Nat Struct Mol Biol,2014,21(12):1 047-1 057.
[4]
Filippakopoulos P,Knapp S.Targeting bromodomains:epigenetic readers of lysine acetylation[J].Nat Rev Drug Discov,2014,13(5):337-356.
[5]
Matzuk MM,McKeown MR,Filippakopoulos P,et al.Small-molecule inhibition of BRDT for male contraception[J].Cell,2012,150(4):673-684.
[6]
Li GQ,Guo WZ,Zhang Y,et al.Suppression of BRD4inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression[J].Oncotarget,2016,7(3):2 462-2 474.
[7]
Huang L,Chen K,Cai ZP,et al.DEPDC1promotes cell proliferation and tumor growth via activation of E2Fsignaling in prostate cancer[J].Biochem Biophys Res Commun,2017,490(3):707-712.
[8]
Gaddis M,Gerrard D,Frietze S,et al.Altering cancer transcriptomes using epigenomic inhibitors[J].Epigenetics Chromatin,2015,8:9.
[9]
Wyatt AW,Gleave ME.Targeting the adaptive molecular landscape of castration-resistant prostate cancer[J].EMBO Mol Med,2015,7(7):878-894.
[10]
Wu X,Liu D,Gao X,et al.Inhibition of BRD4Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma[J].Cell Physiol Biochem,2017,41(5):1 947-1 956.
[11]
Ferri E,Petosa C,McKenna CE.Bromodomains:Structure,function and pharmacology of inhibition[J].Biochem Pharmacol,2016,106:1-18.
[12]
Jung M,Gelato KA,Fernandez-Montalvan A,et al.Targeting BET bromodomains for cancer treatment[J].Epigenomics,2015,7(3):487-501.
Kelly PN,Grabow S,Delbridge AR,et al.Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice[J].Blood,2011,118(24):6 380-6 386.
[15]
Mertz JA,Conery AR,Bryant BM,et al.Targeting MYC dependence in cancer by inhibiting BET bromodomains[J].Proc Natl Acad Sci U S A,2011,108(40):16 669-16 674.
[16]
Baker EK,Taylor S,Gupte A,et al.BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells[J].Sci Rep,2015,5:10 120.