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-  2016 

体质量指数与乳腺癌内分泌耐药相关性的研究进展 Progression of Relationship Between Body Mass Index and Endocrine Therapy Resistance in Breast Cancer

Keywords: 乳腺癌,内分泌耐药,体质量指数

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Abstract:

目前乳腺癌已成为全世界女性最常见的恶性肿瘤之一,其发病率和死亡率在女性恶性肿瘤中位居第二。大量流行病学资料和临床研究表明体质量指数(BMI)与乳腺癌内分泌耐药关系密切。无论是绝经前或者绝经后的乳腺癌患者,升高的BMI均可导致无病生存期(DFS)和总生存期(OS)受损。体质量指数在乳腺癌内分泌治疗耐药机制中的作用有待进一步研究。个体化治疗可能是预防乳腺癌内分泌耐药的积极措施。本文回顾分析了BMI对绝经前和绝经后乳腺癌患者内分泌耐药的影响及可能的机制,希望对临床工作有所帮助

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