Liu Q,Jung J,Somiya M,et al.Virosomes of hepatitis B virus envelope L proteins containing doxorubicin:synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy[J].Int J Nanomedicine,2015,10:4 159-4 172.
[2]
Li X,Liu Y,Xu Z,et al.A complete genomic analysis of hepatitis B virus isolated from 516Chinese patients with different clinical manifestations[J].J Med Virol,2013,85:1 698-1 704.
[3]
Caselmann WH,Meyer M,Kekule AS,et al.A transactivator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA[J].Proc Natl Acad Sci U S A,1990,87(7):2 970-2 974.
[4]
Trautwein C,Schrem H,Tillmann HL,et al.Hepatitis B virus mutations in the pre-S genome before and after liver transplantation[J].Hepatology,1996,24(3):482-488.
[5]
Bock CT,Tillmann HL,Maschek HJ,et al.A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly[J].Gastroenterology,1997,113(6):1 976-1 982.
[6]
Hsieh YH,Su IJ,Wang HC,et al.Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage[J].Carcinogenesis,2004,25(10):2 023-2 032.
[7]
Hung JH,Su IJ,Lei HY,et al.Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2through activation of NF-kappaB and pp38 mitogenactivated protein kinase[J].J Biol Chem,2004,279(45):46 384-46 392.
[8]
Wang HC,Wu HC,Chen CF,et al.Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress[J].Am J Pathol,2003,163(6):2 441-2 449.
[9]
Wang HC,Huang W,Lai MD,et al.Hepatitis B virus pre-S mutants,endoplasmic reticulum stress and hepatocarcinogenesis[J].Cancer Sci,2006,97(8):683-688.
[10]
Ni Y,Sonnabend J,Seitz S,et al.The pre-s2domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly[J].J Virol,2010,84:3 879-3 888.
[11]
Yin J,Xie J,Zhang H,et al.Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma[J].J Gastroenterol,2010,45:1 063-1 071.
[12]
Coppola N,Onorato L,Minichini C,et al.Clinical significance of hepatitis B surface antigen mutants[J].World J Hepatol,2015,7:2 729-2 739.
[13]
Kao JH,Liu CJ,Jow GM,et al.Fine mapping of hepatitis B virus pre-S deletion and its association with hepatocellular carcinoma[J].Liver Int,2012,32:1 373-1 381.
[14]
Fang ZL,Sabin CA,Dong BQ,et al.Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma:a matched nested case-control study[J].J Gen Virol,2008,89:2 882-2 890.
[15]
Gong JY,Liu X,Dong Y,et al.Construction and expression of a recombinant eukaryotic expression plasmid containing the preS1-preS2-S genes of hepatitis B virus and the granulocyte-macrophage colony stimulating factor gene:A study of its immunomodulatory effects[J].Biomed Rep,2013,1:251-256.
[16]
Tajiri H,Takano T,Tanaka H,et al.Hepatocellular carcinoma in children and young patients with chronic HBV infection and the usefulness of alpha-fetoprotein assessment[J].Cancer Med,2016,5:3 102-3 110.
[17]
Yen TT,Yang A,Chiu WT,et al.Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability[J].Oncotarget,2016,7:23 346-23 360.
[18]
Fan YF,Lu CC,Chen WC,et al.Prevalence and significance of hepatitis B virus(HBV)pre-S mutants in serum and liver at different replicative stages of chronic HBV infection[J].Hepatology,2001,33:277-286.
[19]
Mun HS,Lee SA,Kim H,et al.Novel F141Lpre-S2mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections[J].J Virol,2011,85:123-132.
[20]
Liu S,Zhang H,Gu C,et al.Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma:a meta-analysis[J].J Natl Cancer Inst,2009,101:1 066-1 082.
[21]
Kim H,Kim BJ.Association of preS/S Mutations with Occult Hepatitis B Virus(HBV)Infection in South Korea:Transmission Potential of Distinct Occult HBV Variants[J].Int J Mol Sci,2015,16(6):13 595-13 609.
[22]
Su HX,Zhang YH,Zhang ZG et al.High conservation of hepatitis B virus surface genes during maternal vertical transmission despite active and passive vaccination[J]Intervirology,2011,54:122-130.
[23]
Chen BF.Different pre-S deletion patterns and their association with hepatitis B virus genotypes[J].World J Gastroenterol,2016,22:8 041-8 049.
[24]
Utama A,Siburian MD,Fanany I,et al.Hepatitis B virus pre-S2start codon mutations in Indonesian liver disease patients[J].World J Gastroenterol,2012,18:5 418-5 426.
[25]
Huang FY,Wong DK,Seto WK et al.Sequence variations of full-length hepatitis B virus genomes in Chinese patients with HBsAg-negative hepatitis B infection[J].PLoS One,2014,9:e99028.
[26]
Betz-Stablein BD,Topfer A,Littlejohn M,et al.Single-molecule sequencing reveals complex genome variation of hepatitis B virus during 15years of chronic infection following liver transplantation[J].J Virol,2016,90:7 171-7 183.
[27]
Pollicino T,Zanetti AR,Cacciola I,et al.Pre-S2defective hepatitis B virus infection in patients with fulminant hepatitis[J].Hepatology,1997,26:495-499.
[28]
Hsieh YH,Su IJ,Wang HC,et al.Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1through cJun activation domain-binding protein 1[J].Mol Cancer Res,2007,5:1 063-1 072.
[29]
Li Y,Cai Q,Xie Q,et al.Different mechanisms may exist for HBsAg synthesis and secretion during various phases of chronic hepatitis BvVirus infection[J].Med Sci Monit,2017,23:1 385-1 393.
[30]
Skobe M,Hawighorst T,Jackson DG,et al.Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis[J].Nat Med,2001,7:192-198.
