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-  2018 

正中神经刺激对心肌梗死犬室性心律失常的影响 Effect of Median Nerve Stimulation on Ventricular Arrhythmia in a Canine Model With Experimental Myocardial Infarction

Keywords: 心肌梗死,正中神经,室性心律失常,胆碱能抗炎通路

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Abstract:

目的:探讨正中神经刺激(MNS)对心肌梗死后室性心律失常的作用及其机制。方法:15只成年杂种犬制作心梗模型,4周后随机分为MNS1组和MNS2组,MNS1组单纯刺激正中神经,MNS2组刺激前离断双侧迷走神经。两组分别于刺激前后测量心室有效不应期(ERP)及室颤阈值。于基线期、刺激前后取血浆检测肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和乙酰胆碱(ACh)的水平。所有犬于实验终点取心室组织检测梗死周边区TNF-α、IL-6、ACh水平及NF-κB蛋白表达。结果:在正中神经刺激前后,MNS1组和MNS2组心室ERP无明显变化。MNS1组室颤阈值明显高于MNS2组[(20.3±3.7)Vvs(8.7±2.9)V,P<0.01]。MNS1组梗死周边区测得TNF-α、IL-6、NF-κB水平低于MNS2组[TNF-α:(0.21±0.06)ng/mg vs(0.30±0.08)ng/mg,P<0.05;IL-6:(0.16±0.07)ng/mg vs(0.26±0.08)ng/mg,P<0.05;NF-κB:(0.25±0.05)vs(0.44±0.09),P<0.01],而ACh水平较MNS2升高[(18.0±3.9)ng/mg vs(10.0±3.5)ng/mg,P<0.01]。结论:MNS可升高心梗犬的室颤阈值,该影响可能与胆碱能抗炎通路有关

References

[1]  Wang S,Zhou X,Huang B,et al.Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model[J].Heart Rhythm,2015,12(7):1 628-1 635.
[2]  Huang B,Yu L,He B,et al.Renal sympathetic denervation modulates ventricular electrophysiology and has a protective effect on ischaemia-induced ventricular arrhythmia[J].Exp Physiol,2014,99(11):1 467-1 677.
[3]  Guo Z,Zhao Q,Deng H,et al.Renal sympathetic denervation attenuates the ventricular substrate and electrophysiological remodeling in dogs with pacing-induced heart failure[J].Int J Cardiol,2014,175(1):185-186.
[4]  Zhao Q,Zhang S,Zhao H,et al.Median nerve stimulation prevents atrial electrical remodelling and inflammation in a canine model with rapid atrial pacing[J].Europace,2018,20(4):712-718.
[5]  Bardy GH,Lee KL,Mark DB,et al.Home use of automated external defibrillators for sudden cardiac arrest[J].N Engl J Med,2008,358(17):1 793-1 804.
[6]  Jiang H,Lu ZB,Yu Y,et al.Relationship between sympathetic nerve sprouting and repolarization dispersion at peri-infarct zone after myocardial infarction[J].Autonomic Neuroscience:Basic and Clinical,2007,134(1-2):18-25.
[7]  Remo BF,Preminger M,Bradfield J,et al.Safety and efficacy of renal denervation as a novel treatment of ventricular rtachycardia storm in patients with cardiomyopathy[J].Heart Rhythm,2014,11(4):541-546.
[8]  Li P,Pitsillides KF,Rendig SV,et al.Reversal of reflex-induced myocardial ischemia by median nerve stimulation:a feline model of electroacupuncture[J].Circulation,1998,97(12):1 186-1 194.
[9]  Lujan HL,Kramer VJ,DiCarlo SE.Electroacupuncture decreases the susceptibility to ventricular tachycardia in conscious rats by reducing cardiac metabolic demand[J].Am J Physiol Heart Circ Physiol,2007,292(5):H2 550-H2 555.
[10]  Solomon SD,Zelenkofske S,McMurray JJ,et al.Sudden death in patients with myocardial infarction and left ventricular dysfunction,heart failure,or both[J].N Engl J Med,2005,352(25):2 581-2 588.
[11]  朱伟建,张荣宝.躯体传入冲动抑制中枢性心肌缺血的脊髓机制[J].生理学报,1991,43(2):141-148.Zhu WJ,Zhang RB.Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation[J].Acta Physiological Sinica,1991,43(2):141-148.
[12]  Neumann FJ,Ott I,Gawaz M,et al.Cardiac release of cytokines and inflammatory responses in acute myocardial infarction[J].Circulation,1995,92(4):748-755.
[13]  Zhao M,He X,Bi XY,et al.Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia/reperfusion[J].Basic Res Cardiol,2013,108(3):345.
[14]  Adabag AS,Therneau TM,Gersh BJ,et al.Sudden death after myocardial infarction[J].JAMA,2008,300(17):2 022-2 029.
[15]  Rubart M,Zipes DP.Mechanisms of sudden cardiac death[J].J Clin Invest,2005,115(9):2 305-2 315.
[16]  Jardine DL,Charles CJ,Ashton RK,et al.Increased cardiac sympathetic nerve activity following acute myocardial infarction in a sheep model[J].J Physiol,2004,565(Pt1):325-333.
[17]  Ng GA,Mantravadi R,Walker WH,et al.Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution[J].Heart Rhythm,2009,6(5):696-706.
[18]  Vaseghi M,Lux RL,Mahajan A,et al.Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction[J].Am J Physiol Heart Circ Physiol,2012,302(9):H1 838-H1 846.
[19]  Zhou S,Chen LS,Miyauchi Y,et al.Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs[J].Circ Res,2004,95(1):76-83.
[20]  Cao JM,Fishbein MC,Han JB,et al.Relationship between regional cardiac hyperinnervation and ventricular arrhythmia[J].Circulation,2000,101(16):1 960-1 969.
[21]  Tracey KJ.Physiology and immunology of the cholinergic antiinflammatory pathway[J].J Clin Invest,2007,117(2):289-296.
[22]  Meng J.The effects of acupuncture in treatment of coronary heart diseases[J].J Tradit Chin Med,2004,24(1):16-19.

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