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-  2017 

血清淀粉样蛋白基因多态性与重度肥胖儿童血脂的关系 Association of Serum Amyloid A1 Genetic Polymorphism with Serum Lipids in Heavy Obese Children

Keywords: 血清淀粉样蛋白A1,基因多态性,肥胖

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Abstract:

目的:研究血清淀粉样蛋白(SA)A1基因多态性与重度肥胖儿童血脂的关系。方法:选择65名重度肥胖儿童作为研究对象,同时选取65名同性别、同年龄的正常体重儿童作为对照组,分别测量他们的身高、体重,计算体重指数,检测血脂(TC、LDL-C、TG)和SAA浓度并进行对比,同时检测四种单核苷酸多态性(SNPs)的基因型,比较两组儿童四种SNPs的分布频率及各基因型间SAA的浓度。结果:重度肥胖儿童SAA血浆浓度和TC、LDL-C、TG一样明显高于正常对照组,rs12218和rs4638289两种SNPs分别频率在重度肥胖儿童中较正常组高,而其它两组SNPs则在两组儿童中无明显差异,但只有rs4638289基因多态性显示与SAA浓度有关。结论:SAA1基因多态性与重度肥胖儿童血脂密切相关

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