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-  2017 

HIWI2基因rs508485单核苷酸多态性与特发性少精子症的相关性 Assosiation of Single Nucleotide Polymorphisms of HIWI2 rs 508485 with Idiopathic Azoospermia or Oligospermia

Keywords: HIWI2,单核苷酸多态性,特发性少精子症

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Abstract:

目的:研究HIWI2基因rs508485多态性与男性特发性少精症的相关性。方法:选取特发性轻度少精症患者72例及重度少精症患者70例,精液浓度正常男性70例作为对照。提取外周血DNA扩增后采用DNA测序方法检测HIWI2rs508485序列,采用相关回归分析不同基因型与特发性少精症的相关性。结果:对照组中HIWI2rs508485CC型有35例,占55.7%,轻度少精症组CC型有28例,占38.9%,突变型44例,占61.1%,排除年龄、吸烟等相关因素,与对照组相比差异有显著性(OR=1.98,95%CI:1.01-3.98,P=0.0462)。重度少精症CC型占34.4%,突变型占65.6%,与对照组相比差异有显著性(OR=2.40,95%CI:1.18-4.87,P<0.01),结论:HIWI2rs508485的单核苷酸多态性可能与男性特发性少精症相关

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