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-  2017 

APOE基因多态性与血脂异常相关性分析 Apolipoprotein E Gene Polymorphism and Its Effect on Plasma Lipids

Keywords: APOE基因,血脂,用药指导

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Abstract:

目的:了解不同APOE基因型人群与血脂紊乱的相关性,指导合理治疗。方法:收集2015年11月至2016年4月我院高脂血症患者62例[高胆固醇(TC)、高甘油三酯(TG)、高低密度脂蛋白(LDL-C)任其一者]行APOE基因表型检测,根据不同的基因表型分为3组:E2表型组(E2/E2,E2/E3)、E3表型组(E3/E3,E2/E4)、E4表型组(E3/E4,E4/E4),对其结果与脂代谢紊乱相关性进行统计分析,选择性治疗。结果:62例高脂血症患者,其中高TC 21例;高TG 31例;高LDL-C 22例。APOE基因表型组各占比分别为E2型16.13%,E3型64.52%,E4型19.35%。血脂异常类型与APOE基因表型分布:TC异常类型中E4表型组占比最多,为50%;E2表型组占比最少,为10%;TG异常类型中E2表型组占比最多,为70%;E4表型组占比最少,为41.6%。LDL-C异常类型中E4表型组占比最多,为50%;E2表型组占比最少,为20%。3组基因表型TG、LDL-C浓度水平无统计学差异(P>0.05),E2、E3表型组TC浓度水平与E4表型组比较存在统计学差异(P<0.05)。3组均值比较显示E2表型组TG浓度最高,E4表型组TC、LDL-C浓度均值最高。结论:高脂血症是冠心病常见的危险因素,APOE不同的基因表型间个体血脂水平存在差异,临床上可根据APOE不同的基因表型指导患者正确选择调脂药物和饮食干预治疗,以期降低冠心病的发病率和心血管事件风险

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