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-  2017 

促血管生成素-1、血管内皮生长因子在颞叶癫痫海马区的动态表达及意义 Significance and Dynamic Expression of Angiopoietin-1 and VEGF in the Hippocampus of Rats with Temporal Lobe Epilepsy

Keywords: 癫痫,血管生成,血脑屏障,促血管生成素-1,血管内皮生长因子

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Abstract:

目的:探讨促血管生成素-1(Ang-1)、血管内皮生长因子(VEGF)在颞叶癫痫发病机制中的作用。方法:腹腔注射氯化锂-匹罗卡品及生理盐水分别建立颞叶癫痫模型及对照组;观察大鼠行为学改变,比较实验组和对照组大鼠海马区Ang-1、VEGF的时间动态表达过程。结果:抽搐频繁时,海马区Ang-1表达减少;抽搐减少时,海马区Ang-1表达逐渐升至正常;抽搐频繁时,海马区VEGF表达升高;抽搐减少时,海马区VEGF表达逐渐恢复正常;Ang-1与VEGF二者表达呈直线负相关关系。结论:Ang-1与VEGF参与了颞叶癫痫发病机制,可能与海马区Ang-1表达下调,VEGF表达上调有关

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