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-  2017 

神经节苷脂治疗带状疱疹神经痛的临床观察 Clinical Observation of Treating Post-Acute Zoster Pain by Ganglioside M_1

Keywords: 带状疱疹神经痛,带状疱疹,神经节苷脂,老年患者

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Abstract:

目的:观察神经修复药物单唾液酸四己糖神经节苷脂钠(神经节苷脂,GM1)为主的综合疗法治疗老年患者带状疱疹神经痛的临床疗效。方法:将老年带状疱疹神经痛患者随机纳入实验组或对照组,实验组接受以GM1为主的综合治疗,对照组接受除了GM1之外的其他治疗,疗程7d,并在治疗结束后的3-4周对患者进行电话回访,期间用视觉模拟评分法(VAS)和语言评价量表(VRS-4)评价患者疼痛的变化。结果:实验组治疗7d后VAS评分下降了(75±20)%,显著高于对照组的(52±12)%(P=0.007)。治疗7d后,实验组8例患者VRS-4评分下降了2刻度,而对照组仅有4例患者VRS-4评分下降了1刻度,实验组治疗后VRS-4评分的下降幅度显著高于对照组(P=0.001)。3-4周后,实验组5例患者VRS-4评分为0,疼痛完全缓解,而对照组仅有1例患者疼痛完全缓解。结论:以GM1为主的综合治疗可迅速有效地缓解老年患者带状疱疹神经痛,并阻止带状疱疹后遗神经痛的发生

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