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-  2017 

胚胎培养液中低密度脂蛋白受体相关蛋白-1的表达与胚胎质量和妊娠率的关系 Relationship Between LRP-1 Expression of Culture Media and Embryo Quality and Pregnancy Rate

Keywords: 胚胎培养液,低密度脂蛋白受体相关蛋白-1,胚胎分级,妊娠率

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Abstract:

目的:探讨胚胎培养液中低密度脂蛋白受体相关蛋白-1(LRP-1)的表达与胚胎形态学评分及其与移植后妊娠率的关系。方法:收集培养第3天可利用胚胎的培养液,用ELISA方法检测其中LRP-1的表达水平,比较不同胚胎形态学评分间胚胎培养液中LRP-1水平的差异,并比较妊娠组与未妊娠组间移植胚胎培养液中LRP-1水平。结果:(1)优质胚胎对应的培养液中LRP-1的表达水平高于Ⅲ级胚胎的表达水平[(991.79±182.60)pg/ml vs(639.22±108.09)pg/ml],差异具有统计学意义(P<0.05);(2)妊娠组胚胎培养液中LRP-1的表达水平[(1 056.34±166.82)pg/ml]高于未妊娠组的表达水平[(899.46±169.37)pg/ml],差异具有统计学意义(P<0.05)。结论:胚胎培养液中LRP-1的表达水平可作为预测胚胎发育潜能及妊娠结局的参考指标之一

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