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-  2017 

骨桥蛋白在哮喘患儿血清中的表达 Expression of Osteopontin in Serum of Children with Asthma

Keywords: 骨桥蛋白,儿童哮喘,过敏性鼻炎

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Abstract:

目的:检测学龄前及学龄期哮喘患儿血清骨桥蛋白(OPN)水平,探讨儿童哮喘和OPN之间的关系。方法:采用ELISA方法检测50例哮喘儿童及20例健康儿童(对照组)血清OPN。哮喘儿童根据年龄分为学龄前组和学龄组,根据是否合并有过敏性鼻炎再分为子组。结果:哮喘组OPN与对照组相比明显增高(P<0.01),学龄前组患儿血清OPN略增高,但无统计学意义(P>0.05)。学龄组血清OPN较对照组高(P<0.01),同时在学龄组哮喘组中合并有过敏性鼻炎患儿,其血清OPN值较无过敏性鼻炎患儿高(P<0.01)。结论:OPN在学龄期哮喘患儿中是增加的,尤其是合并有过敏性鼻炎患儿

References

[1]  中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2016,54(3):167-181.Respiratory science group,Chinese society of Medicine,Editorial board of Chinese Journal of Pediatrics.Guidelines for the diagnosis and treatment of bronchial asthma in children[J].Chinese Journal of Pediatrics,2016,54(3):167-181.
[2]  Liu W,Xia W,Fan Y,et al.Elevatedserum osteopontin level is associated with blood eosinophilia and asthma comorbidity in patients with allergic rhinitis[J].Allergy Clin Immunol,2012,130(2):1 416-1 418.
[3]  Bacharier L,Guilbert T.Diagnosis and management of early asthma in preschool-aged children[J].Allergy Clin Immunol,2012,130(2):287-296.
[4]  Ducharme FM,Tse SM,Chauhan b,et al.Diagnosis,management,and preschool wheeze[J].Lancet,2014,383(9 928):1 593-1 604.
[5]  Hillas G,Loukides S,Kostikas K,et al.Increased levels of osteopontin insputum supernatant of smoking asthmatics[J].Cytokine,2013,61(2):251-255.
[6]  The Global strategy for asthma management and prevention.Global Initiative for Asthma(GINA)2015.[EB/OL].2015,(Assessed May 2015,at www.ginasthma.org.)
[7]  Samitas K,Zervas E,Vittorakis S,et al.Osteopontin expression and relation to diseaseseverity in human asthma[J].Eur Respir J,2011,37(4):331-341.
[8]  Zhao JJ,Yang L,Zhao FQ,et al.Osteopontin levels are elevated in patients with asthma[J].Int Med Res,2011,39(3):1 402-1 407.
[9]  Konno S,Kurokawa M,Uede T,et al.Role of osteopontin,a multifunctional protein,in allergy and asthma[J].Clin Exp Allergy,2011,41(3):1 360-1 366.
[10]  Brand PL,Caudri D,Eber E,et al.Classification and pharmacological treatment of preschool wheezing:changes since 2008[J].Eur Respir J,2014,43(4):1 172-1 177.
[11]  中华医学会儿科学分会呼吸学组,中华儿科杂志编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-750.Respiratory science group,Chinese society of Medicine,Editorial board of Chinese Journal of Pediatrics.Guidelines for the diagnosis and treatment of bronchial asthma in children[J].Chinese Journal of Pediatrics,2008,46(10):745-750.

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