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-  2015 

复合辅酶对老年患者止血带性心肌损伤的影响 Effect of Biocoen on Tourniquet-Induced Myocardial Injury in Elderly Patients

Keywords: 复合辅酶,止血带,心肌损伤,肌钙蛋白I

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Abstract:

目的:观察复合辅酶对老年患者肢体缺血再灌注后心肌损伤的影响。方法:将40例ASAⅠ-Ⅱ级拟行单侧下肢手术的患者随机分为两组:复合辅酶预处理组(B组,n=20)和对照组(C组,n=20)。B组将复合辅酶0.05U/kg溶于100ml生理盐水中,于上止血带前30min静脉滴注完毕,C组在相同时间内静脉滴注同等体积生理盐水。在下肢缺血初期(T0),缺血末期(T1),再灌注后5 min(T2)、20 min(T3)、4h(T4)、24h(T5)以及72h(T6)采取静脉血3ml,采用酶联免疫吸附测量法(ELISA)测定血清中肌钙蛋白I(cTnI)的水平。结果:与C组相比,在T3、T4、T5时间点,B组血清cTnI水平明显降低(P<0.05),在T6时间点,两组指标差异无统计学意义。结论:复合辅酶对老年患者止血带性心肌损伤具有保护作用

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