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-  2018 

白细胞介素-10与严重脓毒症患者疾病预后的关系 Relationship Between Anti-Inflammatory Cytokine IL-10 Serum Levels and Prognosis of Severe Sepsis Patients

Keywords: 抗炎细胞因子,白细胞介素-10,严重脓毒症,预后,急性生理学和慢性健康评估Ⅱ

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Abstract:

目的:研究抗炎症细胞因子白细胞介素-10(IL-10)在评估严重脓毒症患者疾病预后中的应用。方法:诊断为严重脓毒症的患者78例,收集患者血清,应用化学发光法对IL-10进行检测,收集入ICU 24h内的常规检查并记录APACHE-Ⅱ评分、年龄、性别,记录ICU住院天数,中心事件是28d死亡率。根据脓毒症患者28d临床结局分为存活组和死亡组。结果:78例纳入研究的严重脓毒症患者,年龄:(64.31±16.68)岁,28d随访期间有37例(47.4%)患者死亡,死亡组患者的IL-10明显高于存活组患者(Pearson相关系数为0.056,P=0.7)。受试者工作特征曲线(ROC)曲线显示IL-10水平曲线下面积为0.749(95%CI为62.1%-87.7%,P=0.002)。IL-10对严重脓毒症患者28d死亡率最佳预测临界值为22.8ng/ml,敏感性和特异性分别为66.7%和83.3%。Kaplan-Meier生存曲线显示,IL-10高于22.8ng/ml的患者死亡风险高于IL-10低于22.8ng/ml的患者(P=0.006)。结论:IL-10水平与严重脓毒症患者的预后结局显著相关,它是反映疾病严重程度的指标,可作为判断患者预后情况的生物标志物

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