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-  2018 

长链非编码RNA HULC在结直肠癌中的表达及预后价值 Expression and Prognostic Value of LncRNA HULC in Colorectal Cancer

Keywords: 长链非编码RNA,结直肠癌,诊断,预后

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Abstract:

目的:探讨长链非编码RNA(LncRNA)HULC在结直肠癌(CRC)中的表达及其预后价值。方法:利用实时定量PCR方法检测HULC在结直肠正常黏膜上皮细胞NCM460和CRC细胞,以及在35例CRC组织和配对癌旁组织中的表达情况,并分析其与CRC患者预后的关系。结果:HULC在CRC细胞内的表达水平显著高于NCM460,在CRC组织中的相对表达量为6.801±0.294(n=35),癌旁组织中为3.883±0.309(n=35),差异有统计学意义(P<0.05)。Kaplan-Meier生存分析显示HULC低表达组CRC患者术后的生存时间明显高于高表达组,差异有统计学意义(P<0.05)。结论:HULC在CRC细胞和组织内过表达,可作为CRC预后判断的一个潜在靶点

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