全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

曲马多预处理减少依托咪酯引起的肌阵挛的发生和严重程度 Tramadol Pretreatment Reduces Myoclonus Induced by Etomidate

Keywords: 曲马多,依托咪酯,肌阵挛

Full-Text   Cite this paper   Add to My Lib

Abstract:

目的:分别观察1mg/kg及2mg/kg曲马多预处理对依托咪酯全麻诱导时引起的肌阵挛的预防作用。方法:90例择期全麻手术患者,随机均分为三组(T0、T1、T2,n=30)。全麻诱导前分别预注1 mg/kg曲马多(T1组),2mg/kg曲马多(T2组)或同等剂量的生理盐水(T0组),5min后静注0.3mg/kg依托咪酯并观察有无肌阵挛发生,同时记录肌阵挛的严重程度。间隔1min后予三组均静注0.6mg/kg罗库溴铵,5μg/kg芬太尼行气管插管并同时记录无创动脉血压(BP)和心率(HR)。结果:发生了肌阵挛的患者T0有的28例(93%,n=30),T1组24例(80%,n=30),T2组21例(70%,n=30),预注曲马多的两组诱发肌阵挛的发生率明显低于对照组(P<0.01)。T2组副反应的发生率明显高于T1组和T0组(P<0.05)。结论:曲马多预处理可减少依托咪酯全麻诱导所致的肌阵挛,且剂量为1mg/kg的曲马多预注效果更佳

References

[1]  Huter L,Schreiber T,Gugel M,et al.Low-dose intravenous midazolam reduces etomidate-induced myoclonus:aprospective,randomized study in patients undergoing elective cardioversion[J].Anesth Analg,2007,105(5):1 298-1 302.
[2]  Abreu M,Aguado D,Benito J,et al.Tramadol-induced hyperalgesia and its prevention by ketamine in rats:A randomised experimental study[J].Eur J Anaesthesiol,2015,32(10):735-741.
[3]  曹建平,徐建国.曲马多和哌替啶用于全麻后寒战的预防[J].中华麻醉学杂志,2003,23(3):60-61.Cao JP,Xu JG.Tramadol and Pethidine for the prevention of shivering after general anesthesia[J].Chin J Anesthesiol,2003,23(3):60-61.
[4]  Doenicke AW,Roizen MF,Kugler J,et al.Reducing myoclonus after etomidate[J].Anesthesiology,1999,90(1):113-119.
[5]  Nooraei N,Solhpour A,Mohajerani SA.Priming with atracurium efficiently suppresses etomidate-induced myoclonus[J].Acta Anaesthesiologica Taiwanica,2013,51(4):145-148.
[6]  Miyano K,Minami K,Yokoyama T,et al.Tramadol and its metabolite m1selectively suppress transient receptor potential ankyrin 1activity,but not transient receptor potential vanilloid 1activity[J].Anesth Analg,2015,120(4):790-798.
[7]  El-okdi NS,Lumbrezer D,Karanovic D,et al.Serotonin syndrome after the use of tramadol and ziprasidone in a patient with a deep brain stimulator for Parkinson disease[J].Am J Ther,2014,21(4):e97-e99.
[8]  Wu GN,Xu HJ,Liu FF,et al.Low-dose ketamine pretreatment reduces the incidence and severity of myoclonus induced by etomidate:a randomized,doubleblinded,controlled clinical trial[J].Medicine(Baltimore),2016,95(6):e2701.
[9]  Fassoulaki A,Pateras C,Kaniaris P.Fentanyl in the prevention of etomidate-induced myoclonus[J].Cah Anesthesiol,1987,35(3):201-202.
[10]  Doenicke AW,Roizen MF,Hoernecke R,et al.Solvent for etomidate may cause pain and adverse effects[J].Br J Anaesth,1999,83(3):464-466.
[11]  Ri HS,Shin SW,Kim TK,et al.The proper effect site concentration of remifentanil for prevention of myoclonus after etomidate injection[J].Korean J Anesthesiol,2011,61(2):127-132.
[12]  He L,Ding Y,Chen H,et al.Dezocine pretreatment prevents myoclonus induced by etomidate:a randomized,double-blinded controlled trial[J].J Anesth,2015,29(1):143-145.
[13]  Lv Z,Fang J,Zhu J,et al.Intravenous dezocine pretreatment reduces the incidence and intensity of myoclonus induced by etomidate[J].J Anesth,2014,28(6):944-947.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133