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-  2017 

宫颈癌根治性放疗后引起重度慢性放射性直肠炎的原因分析 Prediction of Severe Late Rectal Toxicity in Cervical Cancer Patients Treated with Definitive Radiotherapy

Keywords: 宫颈癌,重度慢性放射性直肠炎,根治性放疗

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Abstract:

目的:探讨宫颈癌根治性放疗后发生重度慢性放射性直肠炎(SLRT,放射性直肠炎≥3度)的可能因素。方法:收集211例行根治性放疗的宫颈癌患者的临床资料,SPSS 17.0进行统计学分析。结果:18例患者出现SLRT,193例未出现SLRT(NSLRT)。SLRT组与NSLRT组患者3年生存率无明显统计学差异(P>0.05)。单因素和多因素分析示直肠点相当于2Gy分次的生物等效剂量EQD2_R和急性放射性直肠炎(ART)的严重程度是SLRT发生的危险因素(P<0.05)。受试者工作特征(ROC)曲线示EQD2_R引起SLRT的最佳界值为74.3 Gy_3(早反应组织α/β=10,晚反应组织α/β=3),曲线下面积为0.983;ART引起SLRT的最佳界值为2度,曲线下面积为0.892。结论:EQD2_R和ART是SLRT发生的危险因素。宫颈癌根治性放疗时,推荐EQD2_R<74.3 GY_3,并积极治疗ART≥2度者,以减少SLRT的发生

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