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-  2018 

乌司他丁早期干预对老年患者心肺复苏后脑功能的影响 Effect of Ulinastatin Early Intervention on Cerebral Function in Elderly Patients After Cardiopulmonary Resuscitation

Keywords: 乌司他丁,S100β蛋白,尿酸,GCS评分

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Abstract:

目的:探讨老年患者心肺复苏自主循环恢复(ROSC)后血清S100β蛋白(S100β)、尿酸、格拉斯哥评分(GCS)的动态改变,以及乌司他丁早期干预对其影响。方法:心肺复苏ROSC后老年患者42例,随机分为对照组(C组)及乌司他丁组(UTI组),UTI组使用乌司他丁进行早期干预,检测两组在ROSC后0,1,3,7d的血尿酸、S100β以及GCS评分。结果:血尿酸两组于0d时无明显差异(P>0.05),1,3,7d时UTI组高于C组(P<0.01);S100β于0,1d时两组无明显差异(P>0.05),3d、7d时UTI组低于C组(P<0.01);GCS评分在0,1,3d无显著性差异(P>0.05),7d时UTI组高于C组(P<0.01)。结论:乌司他丁能显著提高心肺复苏后脑功能的恢复;这种影响可能与尿酸的抗氧化作用有关

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