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-  2018 

红细胞分布宽度与血管性认知障碍的相关性 Correlation Between Red Blood Cell Distribution Width and Vascular Cognitive Impairment

Keywords: 红细胞分布宽度,血管危险因素,血管性认知障碍

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Abstract:

目的:红细胞分布宽度(RDW)在冠心病中升高并可预测疾病的预后,本研究拟探讨其在血管性认知障碍(VCI)中的作用。方法:这是一项横断面研究,我们纳入了111例伴有血管危险因素的患者,根据弗明汉卒中风险评分(FRSP)分为低危、中危和高危组,比较三组之间RDW水平及认知功能,通过相关性分析判断RDW水平与认知功能的相关性,通过散点图判断随着RDW水平的增高,认知功能的变化趋势,通过相关性分析判断影响RDW水平的因素。结果:随着血管危险因素的增加,RDW水平呈上升趋势,其中低危组、中危组和高危组的RDW水平分别为(12.00±1.29)%,(12.44±0.80)%,(14.03±1.09)%,(P=0.018),而各认知域认知功能均呈下降趋势(P<0.05)。RDW与MMSE、MOCA、RAVLT、DST、VFT、DSST评分均呈负相关(P<0.05),与TMT-A和TMT-B用时呈正相关(P<0.05)。体质量指数、年龄、高血压、糖尿病、吸烟、血脂可能是影响RDW水平的因素。结论:RDW水平随着血管危险因素增多而增高,并且可能帮助判断伴有血管危险因素的患者认知功能损害程度

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