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-  2018 

LGR5与肿瘤发生发展关系的研究进展 Research Advances on the Relationship Between LGR5 and Tumorigenesis

Keywords: LGR5,恶性肿瘤,干细胞,Wnt通路,R-脊椎蛋白

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Abstract:

LGR5是一种表达于多种正常细胞和肿瘤细胞膜的膜蛋白,其与配体R-spodin结合可增强Wnt-β-catenin信号通路,导致肿瘤的进展。LGR5在维持干细胞特性中起着关键作用,可以作为肿瘤干细胞标志物。LGR5靶向治疗能显著抑制肿瘤的生长和转移。本文将通过其与肿瘤关系的研究进行综述

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