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-  2018 

分化型甲状腺癌患者心血管疾病死亡率的实际风险降低 Real-World Risk of Cardiovascular Disease Mortality Is Decreased in Patients with Differentiated Thyroid Cancer

Keywords: 分化型甲状腺癌,心血管疾病,死亡率,风险

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Abstract:

目的:通过SEER数据库中的数据来评估分化型甲状腺癌(DTC)患者的心血管疾病(CVD)死亡风险是否增加,并进一步阐明DTC诊断后心血管死亡率相关的危险因素。方法:对来自SEER数据库的数据进行回顾性分析,以调查DTC患者的CVD死亡率。使用标准死亡率(SMR)来比较SEER队列中DTC患者与美国人群的CVD和全因死亡率。使用相对风险模型和竞争风险模型来检测患者特征与CVD死亡之间的关联。结果:我们纳入了116 151名合格的DTC患者,平均年龄为49.96岁。与一般人群相比,DTC患者CVD死亡率和全因死亡率降低。在不同性别的亚组分析中,我们发现女性DTC患者与一般人群女性相比CVD和全因死亡率下降。DTC男性的CVD死亡率也有所下降,但全因死亡率没有表现出此趋势。在多变量分析中,年龄较大、黑人种族、肿瘤直径超过40mm、淋巴结阳性和甲状腺外肿瘤是导致CVD死亡率增加的危险因素。结论:DTC患者的CVD死亡率实际风险低于一般人群,与性别因素无关

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