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-  2017 

ALDH2双向调节线粒体自噬改善移植肾质量的研究进展 Research Progress on ALDH2 Improving the Quality of Renal Allograft by Bidirectional Regulation of Mitochondrial Autophagy

Keywords: ALDH2,肾移植,线粒体自噬,细胞凋亡,缺血再灌注

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Abstract:

肾移植是治疗终末期肾病的最佳手段,但移植过程中会发生热缺血、冷缺血及缺血再灌注等损伤,影响移植肾近、长期预后。大量研究表明移植肾损伤与线粒体自噬介导的细胞凋亡有密不可分的联系,ALDH2在其中可能扮演着重要的角色。ALDH2可以双向调控线粒体自噬,影响细胞凋亡的进程,减少或增加移植肾损伤。本文综述了ALDH2调控线粒体自噬与移植肾损伤之间的关系,为肾移植领域提出可能的新靶点和研究方向

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