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-  2017 

锰卟啉Mn(Ⅲ)TMPyP在缺血再灌注损伤中的作用 The Role of Mn(Ⅲ) TMPyP in Ischemia/Reperfusion Injury

Keywords: 活性氧,锰卟啉,缺血再灌注

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Abstract:

由缺血再灌注(IR)引起的肝肾损伤的病因与许多介质有关,包括氧化产物、细胞因子和活性氧(ROS)。其中ROS在缺血再灌注损伤(IRI)的过程中起着至关重要的作用,参与许多病理过程如氧化应激、细胞凋亡等过程。锰(Ⅲ)-四(4-N-甲基吡啶基)卟啉(Mn(Ⅲ)TMPyP)作为超氧化物歧化酶(SOD)和过氧化氢酶(CAT)模拟物具有减轻IRI的潜力。本文就Mn(Ⅲ)TMPyP在缺血再灌注方面的研究作一综述

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