Zuniga-Toala A,Zatarain-Barron ZL,Hernandez-Pando R,et al.Nordihydroguaiaretic acid induces Nrf2nuclear translocation in vivo and attenuates renal damage and apoptosis in theischemia and reperfusion model[J].Phytomedicine,2013,20(10):775-779.
[4]
Itoh K,Wakabayashi N,Katoh Y,et al.Keap1regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2in response to electrophiles[J].Genes Cells,2003,8(4):379-391.
[5]
Jaeschke H.Reactiveoxygen and ischemia/reperfusion injury of the liver[J].Chem Biol Interact,1991,79(2):115-136.
[6]
Kudoh K,Uchinami H,Yoshioka M,et al.Nrf2Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice[J].Ann Surg,2014,260(1):118-127.
[7]
Bataille AM,Manautou JE.Nrf2:Apotential target for new therapeutics in liver disease[J].Clin Pharmacol Ther,2012,92(3):340-348.
[8]
Klaassen CD,Reisman SA.Nrf2the rescue:effects of the antioxidative/electrophilic response on the liver[J].Toxicol Appl Pharmacol,2010,244(1):57-65.
[9]
Mcmahon M,Itoh K,Yamamoto M,et al.Keap1-dependent proteasomal degradation of transcription factor Nrf2contributes to the negative regulation of antioxidant response element-driven gene expression[J].J Biol Chem,2003,278(24):21 592-21 600.
[10]
Shih AY,Li P,Murphy T H.A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo[J].J Neurosci,2005,25(44):10 321-10 335.
Lee J M,Calkins MJ,Chan K,et al.Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis[J].J Biol Chem,2003,278(14):12 029-12 038.
[13]
Ke B,Shen XD,Zhang Y,et al.KEAP1-NRF2complex in ischemia-induced hepatocellular damage of mouse liver transplants[J].J Hepatol,2013,59(6):1 200-1 207.
[14]
Kwak MK,Itoh K,Yamamoto M,et al.Enhanced expression of the transcription factor Nrf2by cancer chemopreventive agents:role of antioxidant response element-like sequences in the nrf2promoter[J].Mol Cell Biol,2002,22(9):2 883-2 892.
[15]
Nguyen T,Sherratt PJ,Huang HC,et al.Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element.Degradation of Nrf2by the 26Sproteasome[J].J Biol Chem,2003,278(7):4 536-4 541.
[16]
Morito N,Yoh K,Itoh K,et al.Nrf2regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels[J].Oncogene,2003,22(58):9 275-9 281.
[17]
Enomoto A,Itoh K,Nagayoshi E,et al.High sensitivity of Nrf2knockout mice to acetaminophen hepatotoxicity associated with decreased expression of AREregulated drug metabolizing enzymes and antioxidant genes[J].Toxicol Sci,2001,59(1):169-177.
[18]
Li S,Li J,Shen C,et al.tert-Butylhydroquinone(tBHQ)protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2activation[J].Biochim Biophys Acta,2014,1 841(1):22-33.
[19]
Saykally JN,Rachmany L,Hatic H,et al.The nuclear factor erythroid 2-like 2activator,tert-butylhydroquinone,improves cognitive performance in mice after mild traumatic brain injury[J].Neuroscience,2012,223:305-314.
[20]
Stewart D,Killeen E,Naquin R,et al.Degradation of transcription factor Nrf2via the ubiquitin-proteasome pathway and stabilization by cadmium[J].J Biol Chem,2003,278(4):2 396-2 402.
[21]
Zhang YK,Yeager RL,Tanaka Y,et al.Enhanced expression of Nrf2in mice attenuates the fatty liver produced by a methionine-and choline-deficient diet[J].Toxicol Appl Pharmacol,2010,245(3):326-334.