抑制Kupffer细胞功能对梗阻性黄疸大鼠肝功能的保护作用及其机制 Protective Effect of Kupffer Cell Inhibition on Hepatic Function of Obstructive Jaundice Rats Through Nrf2/HO-1 Signaling Pathway
Nguyen-Lefebvre AT,Horuzsko A.Kupffer Cell Metabolism and Function[J].J Enzymol Metab,2015,1(1):pii:101.
[2]
Merlin S,Bhargava KK,Ranaldo G,et al.Kupffer cell transplantation in mice for elucidating monocyte/macrophage biology and for potential in cell or gene therapy[J].Am J Pathol,2016,186(3):539-551.
[3]
Long Y,Dong X,Yuan Y,et al.etabolomics changes in a rat model of obstructive jaundice:mapping to metabolism of amino acids,carbohydrates and lipids as well as oxidative stress[J].J Clin Biochem Nutr,2015,57(1):50-59.
[4]
Scott CL,Zheng F,De Baetselier P,et al.Bone marrowderived monocytes give rise to self-renewing and fully differentiated Kupffer cells[J].Nat Commun,2016,7:10 321.
[5]
Halaney DL,Zahedivash A,Phipps JE,et al.Differences in forward angular light scattering distributions between M1and M2 macrophages[J].J Biomed Opt,2015,20(11):115 002.
[6]
Hara M,Kono H,Furuya S,et al.Interleukin-17Aplays apivotal role in cholestatic liver fibrosis in mice[J].J Surg Res,2013,183(2):574-582.
[7]
Jones C,Badger SA,Hoper M,et al.Hepatic cytokine response can be modulated using the Kupffer cell blocker gadolinium chloride in obstructive jaundice[J].Int J Surg,2013,11(1):46-51.
[8]
Ahmed SM,Luo L,Namani A,et al.Nrf2signaling pathway:Pivotal roles in inflammation[J].Biochim Biophys Acta,2017,1863(2):585-597.
[9]
Loboda A,Damulewicz M,Pyza E,et al.Role of Nrf2/HO-1system in development,oxidative stress response and diseases:an evolutionarily conserved mechanism[J].Cell Mol Life Sci,2016,73(17):3 221-3 247.
[10]
Abrahám S,Hermesz E,SzabóA,et al.Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice[J].Life Sci,2012,90(3-4):140-146.
