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-  2018 

中性粒细胞与淋巴细胞比值和冠心病关系的探讨 Relationship Between Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease

Keywords: 中性粒细胞,淋巴细胞,冠状动脉粥样硬化

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Abstract:

目的:了解中性粒细胞与淋巴细胞比值(NLR)和冠状动脉狭窄程度的关系,并探讨NLR对冠状动脉粥样硬化性心脏病(冠心病,CAD)的预测价值。方法:回顾性分析我院2013年4月至2016年2月行冠状动脉造影的病人1 055例,其中741例冠心病组病人又根据Gensini评分或SYNTAX评分的三分位数进一步分为三组,另外314例非冠心病患者作为对照组。结果:冠心病组NLR水平高于对照组(P<0.01)。把冠心病组病人根据Gensini评分或SYNTAX评分的三分位数进一步分为三组,与对照组进行四组间的比较,四组间NLR差异仍有统计学意义(P<0.01))。偏相关分析显示NLR水平与冠状动脉狭窄Gensini评分和SYNTAX评分呈正相关(分别是:r=0.213,P<0.01;r=0.127,P<0.01)。多因素Logistic回归分析显示NLR、高血压、吸烟和γ谷氨酰转肽酶(GGT)是冠心病的独立危险因素。受试者工作特征曲线(ROC曲线)显示NLR的曲线下面积为0.644(95%CI:0.609-0.678)。当NLR诊断临界值取3.062 5时,其诊断效能最高,敏感性为40.6%,特异性为80.8%。结论:NLR与冠心病的严重程度显著相关,并对冠心病具有一定的预测价值,可以作为临床医生对冠心病的诊断及评估治疗效果的指标

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