高浓度葡萄糖诱导大鼠肾小球系膜细胞VEGF的表达上调依赖于PKCβⅠ和RhoA的活化 High Glucose Induces Vascular Endothelial Growth Factor Upregulation in Rat Mesangial Cells via Activating PKC BetaⅠ and RhoA
Atkins RC,Zimmet P.Diabetic kidney disease:act now or pay later[J].Saudi J Kidney Dis Transpl,2010,21(2):217-221.
[7]
Schena FP,Gesualdo L.Pathogenetic mechanisms of diabetic nephropathy[J].J Am Soc Nephrol,2005,16(suppl 1):S30-S33.
[8]
Schrijvers BF,Flyvbjierg A,DeVriese AS.The role of vascular endothelial growth factor(VEGF)in renal pathophysiology[J].Kidney Int,2006,65(6):2 003-2 017.
[9]
Krepinsky JC,Li Y,Chang Y,et al.Akt mediates mechanical strain-induced collagen production by mesangial cells[J].J Am Soc Nephrol,2005,16(6):1 661-1 672.
[10]
Shibuya M,Claesson-Welsh L.Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis[J].Exp Cell Res,2006,312(5):549-560.
[11]
Kolavennu V,Zeng L,Peng H,et al.Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control[J].Diabetes,2008,57(3):714-723.
[12]
Noh H,King GL.The role of protein kinase C activation in diabetic nephropathy[J].Kidney Int Suppl,2007,(106):S49-S53.
[13]
Sung SH,Ziyadeh FN,Wang A,et al.Blockade of VEGF signaling ameliorates diabetic albuminuria in mice[J].J Am Soc Nephrol,2006,17(11):3 093-3 104.
Tsuzuki Y,Fukumura D,Oosthuyse B,et al.Vascular endothelial growth factor(VEGF)modulation by targeting hypoxia-induceible factor-l alpha->hypoxia response element->VEGF cascade differently regulates vascular response and growth rate in tumors[J].Cancer Res,2000,60(22):6 248-6 252.
[16]
Massey AR,Miao L,Smith BN,et al.Increased RhoA translocation in renal cortex of diabetic rats[J].Life Sci,2003,72(26):2 943-2 952.
[17]
Gu L,Gao Q,Ni L,et al.Fasudil inhibits epithelialmyofibroblast transdifferentiation of human renal tubular epithelial HK-2cells induced by high glucose[J].Chem Pharm Bull(Tokyo),2013,61(7):688-694.