Méndez-Luna D,Martínez-Archundia M,Maroun RC,et al.Deciphering the GPER/GPR30-agonist and antagonists interactions using molecular modeling studies,molecular dynamics,and docking simulations[J].Biomol Struct Dyn,2015,33(10):2 161-2 172.
[2]
Prossnitz ER,Arterburn JB.Internationalunion of basic and clinical pharmacology.XCVII.G protein-coupled estrogen receptor and its pharmacologic modulators[J].Pharmacol Rev,2015,67(3):505-540.
[3]
Ruiz-Palmero I,Hernando M,Garcia-Segura LM,et al.G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons[J].Mol Cell Endocrinol,2013,372(1-2):105-115.
[4]
De Marco P,Bartella V,Vivacqua A,et al.Insulinlike growth factor-Ⅰregulates GPER expression and function in cancer cells[J].Oncogene,2013,32(6):678-688.
[5]
Kuiper GG,Enmark E,Pelto-Huikko M,et al.Cloning of a novel receptor expressed in rat prostate and ovary[J].Proc Natl Acad Sci USA,1996,93(12):5 925-5 930.
[6]
Borahay MA.Estrogenreceptors and signaling in fibroids:role in pathobiology and therapeutic implications[J].Reprod Sci,2017,24(9):1 235-1 244.
[7]
Owman C,Blay P,Nilsson C,et al.Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues[J].Biochem Biophys Res Commun,1996,228(2):285-292.
[8]
Plante BJ,Lessey BA,Taylor RN,et al.G proteincoupled estrogen receptor(GPER)expression in normal and abnormal endometrium[J].Reprod Sci,2012,19(7):684-693.
[9]
Akama KT,Thompson LI,Milner TA,et al.Postsynaptic density-95(PSD-95)binding capacity of Gprotein-coupled receptor 30(GPR30),an estrogen receptor that can be identified in hippocampal dendritic spines[J].Biol Chem,2013,288(9):6 438-6 450.
[10]
Almey A,Filardo EJ,Milner TA,et al.Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats:Evidence for cholinergic but not dopaminergic colocalization[J].Endocrinology,2012,153(11):5 373-5 383.
[11]
Wang C,Liu Y,Cao JM.G protein-coupled receptors:Extranuclear mediators for the non-genomic actions of steroids[J].Mol Sci,2014,15(9):15 412-15 425.
[12]
Barton M.Not lost in translation:Emerging clinical importance of the G protein-coupled estrogen receptor GPER[J].Steroids,2016,111:37-45.
[13]
Broselid S,Berg KA,Chavera TA,et al.G proteincoupled receptor 30(GPR30)forms a plasma membrane complex with membrane-associated guanylate kinases(MAGUKs)and protein kinase a-anchoring protein 5(AKAP5)that constitutively inhibits cAMP production[J].Biol Chem,2014,289(32):22 117-22 127.
[14]
Vossler MR,Yao H,York RD,et al.cAMP activates MAP kinase and Elk-1through a B-Raf-and Rap1-dependent pathway[J].Cell,1997,89(1):73-82.
[15]
Pietras RJ,Szego CM.Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells[J].Nature,1977,265(5 589):69-72.
[16]
Ariazi EA,Brailoiu E,Yerrum S,et al.The G protein-coupled receptor GPR30inhibits proliferation of estrogen receptor-positive breast cancer cells[J].Cancer Res,2010,70(3):1 184-1 194.
[17]
Filardo EJ,Quinn JA,Frackelton AR,et al.Estrogen action via the G protein-coupled receptor,GPR30:Stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-toMAPK signaling axis[J].Mol Endocrinol,2002,16(1):70-84.
[18]
Prossnitz ER,Barton M.The G-protein-coupled estrogen receptor GPER in health and disease[J].Nat Rev Endocrinol,2011,7(12):715-726.
[19]
Soloff MS,Szego CM.Purification of estradiol receptor from rat uterus and blockade of its estrogen-binding function by specific antibody[J].Biochem Biophys Res Commun,1969,34(1):141-147.
[20]
Vrtaˇcnik P,Ostanek B,Mencej-Bedraˇc S,et al.The many faces of estrogen signaling[J].Biochem Medica,2014,24(3):329-342.
[21]
Vasudevan N,Pfaff DW.Membrane-initiated actions of estrogens in neuroendocrinology:Emerging principles[J].Endocr Rev,2007,28(1):1-19.
Olde B,Leeb-Lundberg LMF.GPR30/GPER1:searching for a role in estrogen physiology[J].Trends Endocrinol Metab,2009,20(8):409-416.
[24]
江梦南,罗雪,沈雨濛,等.雌激素受体GPR30介导的小鼠视网膜神经节细胞保护作用[J].武汉大学学报:医学版,2016,37(2):195-199.Jiang MN,Luo X,Shen YM,et al.Neuroprotection of Estrogen receptor GPR30in retinal ganglion cell.[J]Medical Journal of Wuhan University,2016,37(2):195-199.
[25]
Lindsey SH,da Silva AS,Silva MS,et al.Reduced vasorelaxation to estradiol and G-1in aged female and adult male rats is associated with GPR30downregulation[J].Am J Physiol Endocrinol Metab,2013,305(1):E113-E118.
[26]
Lindsey SH,Liu L,Chappell MC.Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling[J].Steroids,2014,81:99-102.
[27]
Szego CM,Davis JS.Adenosine 3′,5′-monophosphate in rat uterus:Acute elevation by estrogen[J].Proc Natl Acad Sci USA,1967,58(4):1 711-1 718.
[28]
Srivastava DP,Evans PD.G-protein oestrogen receptor 1:Trials and tribulations of a membrane oestrogen receptor[J].Neuroendocrinol,2013,25(11):1 219-1 230.
[29]
Hammond R,Nelson D,Gibbs RB.GPR30co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus[J].Psychoneuroendocrinology,2011,36(2):182-192.
[30]
Pupo M,Vivacqua A,Perrotta I,et al.The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts(CAFs)[J].Mol Cell Endocrinol,2013,376(1-2):23-32.
[31]
Samartzis EP,Noske A,Meisel A,et al.The G protein-coupled estrogen receptor(GPER)is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer[J].PLoS One,2014,9(1):e83296.
[32]
Dennis MK,Field AS,Burai R,et al.Identification of a GPER/GPR30antagonist with improved estrogen receptor counterselectivity[J].Steroid Biochem Mol Biol,2011,127(3-5):358-366.
[33]
Filardo EJ,Quinn JA,Bland KI,et al.Estrogen-induced activation of Erk-1and Erk-2requires the G protein-coupled receptor homolog,GPR30,and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF[J].Mol Endocrinol,2000,14(10):1 649-1 660.
[34]
Pinton P,Giorgi C,Siviero R,et al.Calcium and apoptosis:ER-mitochondria Ca2+transfer in the control of apoptosis[J].Oncogene,2008,27(50):6 407-6 418.
[35]
Vaziri-Gohar A,Houston KD.GPER1-mediated IGFBP-1induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells[J].Mol Cell Endocrinol,2016,422:160-171.
