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-  2018 

姜黄素通过内质网应激途径诱导肺癌A549细胞凋亡 Curcumin Induces Lung Cancer A549 Cells Apoptosis Through Endoplasmic Reticulum Stress

Keywords: 姜黄素,肺癌,凋亡,内质网应激

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Abstract:

目的:观察姜黄素诱导肺癌A549细胞的凋亡并探讨其相关机制。方法:传代培养肺癌A549细胞,分别给予姜黄素0,5,10,20,40μmol/ml处理,观察各组细胞增殖能力、细胞凋亡率、葡萄糖调节蛋白78(GPR78)、CAAT/增强子结合蛋白同源蛋白(CHOP)和半胱氨酸天冬氨酸蛋白酶-12(Caspase-12)蛋白表达。结果:姜黄素作用A549细胞后,细胞增殖能力下降,细胞凋亡率升高,GPR78、CHOP和Caspase-12蛋白表达均升高,这些改变随剂量增加而明显(P均<0.05)。结论:姜黄素可能通过内质网应激途径诱导肺癌A549细胞调亡,这一作用在一定范围具有剂量依赖性

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