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-  2018 

8Spheres微球联合碘油TACE治疗原发性肝癌的疗效及安全性 Efficacy and Safety Analysis of 8Spheres Microspheres Combined with Lipiodol TACE in the Treatment of Hepatocellular Carcinoma

Keywords: 肝癌,肝动脉化疗栓塞,疗效,安全性,8Spheres栓塞微球

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Abstract:

目的:探讨8Spheres适形栓塞微球联合碘油肝动脉化疗栓塞(TACE)治疗原发性肝癌的近期疗效及安全性。方法:收集我院原发性肝癌患者共64例。其中试验组(8Spheres栓塞微球+碘油栓塞)32例,对照组(单纯碘油栓塞)32例。比较两组患者介入治疗前及治疗后1周、1个月肝功能指标及甲胎蛋白(AFP)的变化。术后3个月、6个月评价两组患者肿瘤局部反应。同时比较两组患者术后并发症发生情况。结果:患者基线临床特征无统计学差异(均P>0.05)。术后1个月两组患者肝功能均改善,但试验组肝功能指标ALT、AST和TBiL明显优于对照组(均P<0.05)。术后1周及1个月AFP水平显著下降(均P<0.01),且术后1个月试验组AFP水平显著低于对照组(P<0.01)。术后6个月试验组肿瘤客观反应率(P<0.05)及疾病控制率(P<0.01)均显著高于对照组,且试验组疾病进展率显著低于对照组(P<0.01)。两组患者术后总并发症发生率无显著性差异(P>0.05)。结论:与单纯碘油TACE相比,8Spheres栓塞微球联合碘油TACE对治疗原发性肝癌近期疗效显著,安全性较高,值得临床推广。其远期临床疗效及生存获益有待进一步随访研究

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