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-  2018 

Sox2,Pten,Stat3,Vegf在皮肤恶性黑色素瘤和交界痣中表达的差异性 Expression Difference of Sox2,Pten,Stat3,and Vegf Genes Between Cutaneous Malignant Melanoma and Junctional Nevi

Keywords: 皮肤恶性黑色素瘤,交界痣,Sox2,Pten,Stat3,Vegf

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Abstract:

目的:探讨SOX区域Y相关高迁移率族蛋白基因2(Sox2)、人第10号染色体缺失的磷酸酶及张力蛋白同源基因(Pten)、信号传导子与转录激活子3(Stat3),、血管内皮细胞生长因子(Vegf)在皮肤恶性黑色素瘤(CMM)、交界痣中表达的差异。方法:免疫组织化学染色方法检测了27例CMM、10例交界痣组织蜡块中Sox2,Pten,Stat3,Vegf的表达,统计学分析CMM组和交界痣组四者表达的差异。结果:在CMM和交界痣中,Sox2、Pten的表达有显著差异(P<0.05),Sox2在CMM表达显著高于交界痣,Pten在CMM表达显著低于交界痣,Stat3、Vegf的表达两组间无明显差异(P>0.05)。结论:Sox2在CMM中的表达显著高于交界痣,Pten在CMM中的表达显著低于交界痣,Sox2、Pten可能在黑色素细胞恶变中起到一定作用;Stat3、Vegf的表达两组间无明显差异,可能未直接参与CMM的发生

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