Chen W,Miao YQ,Fan DJ,et al.Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats[J].AAPS PharmSciTech,2011,12(2):705-711.
[2]
Guo S,Nighot M,Al-Sadi R,et al.Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4signal transduction pathway activation of FAK and MyD88[J].J Immunol,2015,195(10):4 999-5 010.
[3]
Dong H,Wang N,Zhao L,et al.Berberine in the Treatment of Type 2 Diabetes Mellitus:A Systemic Review and Meta-Analysis[J].Evid Based Complement Alternat Med,2012,2012:1-12.
[4]
Ridaura VK,Faith JJ,Rey FE,et al.Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science,2013,341(6 150):1 241 214.
[5]
Gong J,Hu M,Huang Z,et al.Berberine attenuates intestinal mucosal barrier dysfunction in type 2diabetic rats[J].Front Pharmacol,2017,8:42.
[6]
Li HM,Wang YY,Wang HD,et al.Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2adrenoceptor-independent mechanisms[J].Acta Pharmacol Sin,2011,32(11):1 364-1 372.
[7]
Cao M,Wang P,Sun C,et al.Amelioration of IFNgamma and TNF-alpha-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCKMLC phosphorylation signaling pathway[J].PLoS One,2013,8(5):e61944.
[8]
Gonzalez-Mariscal L,Tapia R,Chamorro D.Crosstalk of tight junction components with signaling pathways[J].Biochim Biophys Acta,2008,1778(3):729-756.
[9]
Guo S,Al-Sadi R,Said H M,et al.Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14[J].Am J Pathol,2013,182(2):375-387.
[10]
Everard A,Cani PD.Diabetes,obesity and gut microbiota[J].Best Pract Res Clin Gastroenterol,2013,27(1):73-83.
[11]
Horton F,Wright J,Smith L,et al.Increased intestinal permeability to oral chromium(51Cr)-EDTA in human Type 2diabetes[J].Diabetic Medicine,2014,31(5):559-563.
[12]
Fu Q,Wang H,Xia M,et al.The effect of phytic acid on tight junctions in the human intestinal Caco-2cell line and its mechanism[J].Eur J Pharm Sci,2015,80:1-8.
[13]
Pussinen PJ,Havulinna AS,Lehto M,et al.Endotoxemia is associated with an increased risk of incident diabetes[J].Diabetes Care,2011,34(2):392-397.
[14]
Zhang X,Zhao Y,Xu J,et al.Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats[J].Sci Rep,2015,5:14 405.
[15]
Gu L,Li N,Gong J,et al.Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia[J].J Infect Dis,2011,203(11):1 602-1 612.
