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-  2018 

WDR1在肝癌组织中的表达及其与长期预后的关系 Expression of WDR1 in Hepatocellular Carcinoma Tissue and Its Relation to the Long-Term Prognosis

Keywords: WD40重复包含蛋白1,肝细胞癌,无瘤生存率,总体生存率

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Abstract:

目的:探究WD40重复包含蛋白1(WDR1)在原发性肝癌组织中的表达以及临床价值。方法:免疫组织化学法检测106例肝细胞癌(HCC)患者的肝癌组织标本中WDR1的表达情况,统计分析WDR1与病理资料的关系及其与HCC患者长期预后的关系。结果:较之于癌旁组织,WDR1在肝癌组织中为阳性高表达。HCC中WDR1的高低表达情况与甲胎蛋白(AFP)、肝硬化、微血管侵犯、Child-Pugh分级、TNM分期等临床病理特征存在显著的相关性(P<0.05),而和肿瘤大小、性别等其余临床病理特征的相关性不明显(P>0.05)。COX回归分析表明WDR1是HCC患者总体生存预后的独立影响因素(HR=1.764,95%CI:1.270-2.841,P<0.05),也是HCC患者无瘤生存预后的独立影响因素(HR=1.803,95%CI:1.328-2.755,P<0.05)。Kaplan-Meier生存分析结果显示WDR1高表达组的总体生存率和无瘤生存率均显著低于WDR1低表达组。结论:WDR1是HCC患者的独立预后危险因素,且WDR1高表达者预后差

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