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-  2018 

阻断颞叶海马区血供癫痫大鼠模型的制备 Establishment a Rat Epilepsy Model by Blocking the Blood Supply of Hippocampus in Temporal Lobe

Keywords: 癫痫,疾病模型,匹罗卡品,大鼠

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Abstract:

目的:探讨一种新型的颞叶癫痫模型的制备。方法:选择成年雄性SD大鼠60只随机分为注射匹罗卡品组(对照组)、新型模型组(实验组)、假手术组,每组20只动物,观察各组大鼠的成功率,模型大鼠癫痫发作级别及癫痫行为Racinel评分,同时观察模型大鼠癫痫发作时的脑电图。结果:成功获得各组癫痫模型动物,各组大鼠Racinel评分差异无统计学意义(P>0.05),但是新型模型组在制备成功率、存活率上均明显优于对照组(P<0.05)。结论:与传统的匹罗卡品点燃模型相比,新型制备组癫痫动物成功率高,癫痫行为保持时间较久,能更好的为临床和基础研究所应用

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