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-  2018 

HOXC10高表达与鼻咽癌患者预后的相关性分析 Correlation Analysis Between High Expression of HOXC10 and Prognosis of Nasopharyngeal Carcinoma Patients

Keywords: HOXC10,鼻咽癌,预后

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Abstract:

目的:探讨HOXC10在鼻咽癌中的表达及其与鼻咽癌患者预后的相关性。方法:采用荧光定量PCR及免疫组织化学的方法对124例无转移的鼻咽癌患者组织中HOXC10 mRNA及蛋白水平表达进行检测。用Chisquare检验对HOXC10的表达与鼻咽癌患者临床病理资料间的相关性进行分析。并采用Kaplan-Meier对HOXC10表达水平与鼻咽癌患者生存率包括疾病特异性生存率(DSS),无转移生存率(MeFS),局部无复发生存率(LRFS)间的相关性进行分析。结果:在鼻咽癌组织中HOXC10表达上调,而HOXC10的高表达与鼻咽癌患者的肿瘤分期(P=0.021)及淋巴结转移(P<0.001)显著相关。单变量分析发现,就DSS(P=0.007)和MeFS(P=0.004 2)而言,HOXC10高表达与鼻咽癌患者差的预后呈正向关。多变量分析发现,HOXC10高表达在预测DSS(P=0.018,风险比=1.988)和MeFS(P=0.026,风险比=1.899)方面仍然是一个独立的预后因子,并且DSS(P=0.026)、MeFS(P=0.033)和LRFS(P=0.014)与鼻咽癌患者的肿瘤分期存在明显的相关性。结论:HOXC10在鼻咽癌中的表达及其与鼻咽癌患者预后存在密切相关性,可能作为鼻咽癌患者预后的一个的生物标志物

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