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-  2017 

双背侧前额叶低频重复经颅磁刺激治疗精神分裂症顽固性幻听的疗效和安全性 Self-Control Study of Low-Frequency Repetitive Transcranial Magnetic Stimulation in the Patients with Auditory Hallucination of Schizophrenia

Keywords: 低频重复经颅磁刺激,精神分裂症,顽固性幻听,自身前后对照试验

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Abstract:

目的:探讨精神分裂症患者采用双背侧前额叶低频重复经颅磁刺激(rTMS)对顽固性幻听的治疗效果及安全性。方法:选取我院2013年1月至2015年1月收治的顽固性幻听精神分裂症患者共48例,给予双背侧前额叶低频重复经颅磁刺激法,比较患者治疗前后幻听症状、精神分裂阳性及阴性症状量表(PNASS)评分、临床疗效总印象表(CGI)及简易智力状况检查法(MMSE)评分,安全性评估采用不良反应症状量表(TESS)评估。结果:患者治疗后PNASS评分中幻听评分、阳性症状及总评分均低于治疗前,P<0.05。治疗后患者MMSE评分及CGI中GI评分明显高于治疗前,P<0.05。TESS评估有2人出现头晕、头疼。结论:伴有顽固性幻听的精神分裂症患者采用低频重复经颅磁刺激治疗可以有效缓解幻听及相关症状,安全性高,无明显不良反应

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