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-  2018 

不明原因复发性流产母胎界面蜕膜组织NK细胞及T淋巴细胞亚群的变化 Change of Natural Killer and T Lymphocyte Subsets in Maternal-Fetal Interface in Unexplained Recurrent Spontaneous Abortion

Keywords: 不明原因复发性流产,母胎界面,免疫,相关性

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Abstract:

目的:研究不明原因复发性流产发生时母胎界面蜕膜组织中(1)CD4~+T细胞及CD8~+T细胞的变化;(2)子宫自然杀伤细胞CD56~+CD16~+NK细胞的变化;(3)CD4~+辅助性T细胞Th1、Th2及其细胞因子的变化,探讨不明原因复发性流产发生机制。方法:采用流式细胞技术分别检测正常早孕实施计划生育手术妇女30例(正常早孕组)和不明原因复发性流产妇女30例(URSA组)母胎界面蜕膜组织中CD4~+T细胞、CD8~+T细胞、CD56~+CD16~+NK细胞、Th1及Th2细胞所分泌的细胞因子数量的百分比。结果:(1)URSA组患者CD4~+T细胞、CD56~+CD16~+NK细胞百分比明显高于正常早孕组,CD8~+T细胞百分比明显低于正常早孕组(P<0.05);(2)URSA组Th1细胞、Th1/Th2比率明显高于正常早孕组(P<0.01)。结论:母胎界面局部T淋巴细胞亚群、子宫自然杀伤细胞亚群比例的改变及Th1细胞增多与不明原因复发性流产相关

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