全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2018 

瘦素受体基因多态性与消化道肿瘤研究进展 Research Progress of Leptin Receptor Gene Polymorphism Associated with Gastrointestinal Cancer

Keywords: 瘦素受体,基因多态性,消化道肿瘤

Full-Text   Cite this paper   Add to My Lib

Abstract:

瘦素是一种多靶向性且作用广泛的蛋白激素,由肥胖基因编码,主要通过与瘦素受体结合来调节机体能量代谢及脂肪沉积。其还参与炎性反应、损伤修复及肿瘤生长等病理过程。瘦素受体广泛分布于体内,已发现其有多种基因多态性。近年来研究显示,瘦素受体基因多态性与多种肿瘤的发生发展密切有关,包括对消化道肿瘤的影响。本文将从瘦素受体基因多态性、表达与功能、受体信号传导、基因多态性与消化道肿瘤、基因多态性与其他肿瘤等5个方面就瘦素受体基因多态性与消化道肿瘤的关系进行综述

References

[1]  Cheung CC,Clifton DK,Steiner RA,et al.Pro-piomelanocortion neurons are direct targets for leptin in the hypothalamus[J].Endocrinology,1997,138:4 489-4 492.
[2]  刘晖,徐渭贤,曹丽静,等.瘦素和瘦素受体在结直肠癌中的表达及临床意义[J].河北医药,2009,31(20):2 700-2 701.Liu H,Xu WX,Cao LJ,et al.Expression and clinical significance of leptin and leptin receptor in colorectal cancer[J].Hebei Medical Journal,2009,31(20):2 700-2 701.
[3]  Slattery ML,Wolff RK,Herrick J,et al.Leptin and leptin receptor genotypes and colon cancer:gene-gene and gene-lifestyle interactions[J].Int J Cancer,2008,122:1 611-1 617.
[4]  Vasku A,Vokurka J,Bienertova-Vasku J,et al.Obesity-related genes variability in Czech patients with sporadic colorectal cancer[J].Int J Colorectal Dis,2009,24(3):289-294.
[5]  Liu L,Zhong R,Wei S,et al.The leptin gene family and colorectal cancer:interaction with smoking behavior and family history of cancer[J].PLoS One,2013,8(4):e60777.
[6]  Testa R,Franceschini R,Giannin E,et al.Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis[J].Hepatol,2000,33(1):33-37.
[7]  El-Hussiny MA,Atwa MA,Rashad WE,et al.Leptin receptor Q223R polymorphism in Egyptian female patients with breast cancer[J].Contemp Oncol(Pozn),2017,21(1):42-47.
[8]  Mahmoudi R,Noori Alavicheh B,Nazer Mozaffari MA,et al.Polymorphisms of leptin(-2548G/A)and leptin receptor(Q223R)genes in iranian women with breast cancer[J].International Journal of Genomics,2015,10:1 155.
[9]  Mikhail AA,Beck EX,Shafer A,et al.Leptin stimulates fetal and adult erythroid and myeloid development[J].Blood,1997,89:1 507-1 512.
[10]  姚红,郝素珍,原素梅,等.胃黏膜瘦素和瘦素受体的表达及信号转导[J].山西医科大学学报,2004,35(2):122-125.Yao H,Hao SZ,Yuan SM,et al.Expression and signaling of leptin and its receptors in Helicobacter pyloriassociated gastritis[J].Journal of Shanxi Medical University,2004,35(2):122-125.
[11]  Dong Z,Xu X,Du L,et al.Leptin-mediated regulation of MT1-MMP localization is KIF1I3-dependent and enhances gastric cancer cell invasion[J].Carcinogenesis,2013,31(4):989-997.
[12]  Kim EY,Chin HM,Park SM,et al.Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea[J].Korean Surg Soc,2012,83:7-13.
[13]  Pai R,Lin C,Tran T,et al.Leptin activates STAT and ERK2path ways and induces gastric caner cell proliferation[J].Biochem Biophys Res Commun,2005,331(4):984-992.
[14]  Mostafa RT,Akram S,Mohammad RZ,et al.The association between polymorphismsin insulin and obesity related genesand risk of colorectal cancer[J].Iran J Cancer Prev,2013,6(4):179-185.
[15]  Doecke JD,Zhao ZZ,Stark MS,et al.Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers[J].Cancer Epidemiol Biomarkers Prev,2008,17(4):1 007-1 210.
[16]  Rodrigo C,Tennekoon KH,Karunanayake EH,et al.Circulating leptin,soluble leptin receptor,free leptin index,visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer[J].Endocr J,2017,64(4):393-401.
[17]  Liu P,Shi H,Liu R,et al.Lack of association between LEPR Q223Rpolymorphisms and cancer susceptibility:evidence from a meta-analysis[J].J BUON,2014,19(3):855-862.
[18]  Matsuoka N,Ogawa Y,Hosoda K,et al.Human leptin receptor gene in obese Japanese subjects:evidence against either obesity-causing mutations or association of sequence variants with obesity[J].Diabetologia,1997,40(10):1 204-1 210.
[19]  Harvey J,Ashford MLJ.Leptin in the CNS:much more than a satiety signal[J].Neuropharmacology,2003,44:845-854.
[20]  Schnerder R,Bomstein SR,Chrousos GP,et al.Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor[J].Hom Metab Res,2001,33(1):1-6.
[21]  赵亮,沈志祥,沈磊,等.瘦素受体异构体ob-Ra和obRb在胃腺癌组织中的表达[J].武汉大学学报:医学版,2008,29(5):626-630.Zhao L,Shen ZX,Shen L,et al.Expression of leptin receptor isomer ob-Ra and ob-Rb in gastric adenocarcinoma[J].Medical Journal of Wuhan University,2008,29(5):626-630.
[22]  应俊,应俊林,李佩珍,等.瘦素受体基因Pro1019Pro变异与温州地区胃癌的相关性研究[J].中国卫生检验杂志,2010,20(5):1 135-1 136.Ying J,Ying JL,Li PZ,et al.Association between Pro1019Pro mutation of leptin receptor gene and gastric cancer in Wenzhou area[J].Chinese Journal of Health Laboratory Technology,2010,20(5):1 135-1 136.
[23]  沈磊,周晶,雷伟,等.瘦素及其受体与原发性肝癌关系的初步研究[J].中华肝脏病杂志,2006,14(10):777-779.Shen L,Zhou J,Lei W,et al.A preliminary study of the relationship between leptin and its receptor and primary hepatocellular carcinoma[J].Chin J Hepatol,2006,14(10):777-779.
[24]  戴锴,陈静,杨丽华,等.瘦素水平及其受体基因多态性与原发性肝癌的相关性研究[J].胃肠病学和肝病杂志,2010,19(8):722-724.Dai K,Cheng J,Yang LH,et al.The relationship of serum leptin and leptin receptor polymorphisms with primary hepatocellular carcinoma[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(8):722-724.
[25]  Li YL,Geng JL,Wang YZ,et al.The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients[J].Cancer Research and Clinical Oncology,2012,138(2):311-316.
[26]  Skibola F,Holly A,Forrest S,et al.Body mass index,leptin and leptin receptor polymorphisms,and nonhodgkinl ymphoma[J].Cancer Epidemiology,2004,13,(5):779-786.
[27]  Marcello MA,Calixto AR,de Almeida JF,et al.Polymorphism in LEP and LEPR may modify leptin levels and represent risk factors for thyroid cancer[J].Int J Endocrinol,2015,2015:173 218.
[28]  Liu PC,Yang YJ,Liu R,et al.Lack of association between LEPR Lys656Asn or Ser343Ser polymorphisms and cancer susceptibility:A meta-analysis[J].Biomed Rep,2014,2(6):849-854.
[29]  Pechlivanis S,Bermejo JL,Pardini B,et al.Genetic variation in adipokine genes and risk of colorectal cancer[J].Eur J Endocrinol,2009,160(6):933-940.
[30]  Li Z,Yuan W,Ning S,et al.Role of leptin receptor(LEPR)gene polymorphisms and haplotypes in susceptibility to hepatocellular carcinoma in subjects with chronic hepatitis B virus infection[J].Mol Diagn Ther,2012,16(6):383-388.
[31]  Babic A,Bao Y,Qian ZR,et al.Pancreatic cancer risk associated with prediagnostic plasma levels of leptin and leptin receptor genetic polymorphisms[J].Cancer Prev,2016,15(24):7 160-7 167.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133