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-  2018 

丹参酮ⅡA通过调节NF-κB通路对肥大细胞介导的过敏性鼻炎的影响 Effects of Tanshinone ⅡA on Mast Cell Mediated Rhinallergosis by Regulating the NF-Kappa B Pathway

Keywords: 丹参酮ⅡA,过敏性鼻炎,肥大细胞,NF-κB通路,炎症因子

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Abstract:

目的:研究丹参酮ⅡA(TanⅡA)对肥大细胞介导的过敏性鼻炎的影响,并探讨其具体作用机制。方法:给予过敏性鼻炎模型小鼠及肥大细胞TanⅡA预处理,观察模型小鼠卵清蛋白(OVA)所诱导的过敏性鼻炎反应及二硝基苯基化人血清白蛋白(DNP-HSA)所诱导的肥大细胞脱颗粒现象,测定肥大细胞核转录因子kappa B(NF-κB)通路及其下游炎症因子肿瘤坏死因子(TNF)-α和白细胞介素(IL)-4的表达。结果:TanⅡA可缓解模型小鼠组胺释放、IgE产生及血管舒张等过敏性鼻炎反应,并抑制肥大细胞的脱颗粒,抑制NF-κB通路的激活下调炎症因子TNF-α和IL-4的表达。结论:TanⅡA通过抑制NF-κB通路的激活从而缓解由肥大细胞介导的过敏性鼻炎反应

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