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-  2015 

促性腺激素释放激素激动剂治疗围绝经期子宫肌瘤的临床价值 Clinical Value of GnRH-a in Treating Perimenopausal Uterus Myoma

Keywords: GnRH-a,围绝经期,子宫肌瘤

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Abstract:

目的:探讨促性腺激素释放激素激动剂(GnRH-a)治疗围绝经期子宫肌瘤的临床价值。方法:将2009年1月至2010年1月在我院门诊就诊的40例确诊为子宫肌瘤的患者给予药物治疗,皮下注射长效GnRH-a制剂(抑那通),3.75mg,每4周1次,连用6月。治疗前后均行彩色超声监测子宫及肌瘤大小,监测血常规、肝功能以及症状改善情况,监测血清卵泡刺激素(FSH)、黄体生成素(LH)、雌激素(E2)、孕酮(P)水平以及治疗期间出现的副反应。结果:40例患者在治疗期间均出现闭经,继发贫血得以纠正。子宫体积由(332.64±40.46)cm3减小为(205.17±12.54)cm3,肌瘤体积由(61.31±1.30)cm3减小为(34.01±5.80)cm3,均明显缩小(P<0.05)。治疗后血清激素FSH、LH、E2及P水平均显著下降(P<0.05),其中以E2下降最为显著(P<0.01)。短期治疗副作用主要为低雌激素症状,但发生率低。结论:短期应用GnRH-a治疗围绝经期子宫肌瘤效果明显,副反应轻微,是目前理想的药物治疗方法之一

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