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-  2015 

HIV-1与γδT细胞相互作用机制的研究进展 Progresses in the Study of the Interaction Mechanism Between HIV-1 and Gamma Delta T Cells

Keywords: HIV-1,γδT细胞,机制

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Abstract:

γδT细胞是外周血T淋巴细胞的重要组成部分,分为Vδ1T和Vδ2T细胞亚群。γδT细胞在控制HIV-1感染中发挥着重要作用。HIV-1感染会增加Vδ1T细胞数量而减少Vδ2T细胞数量,这种改变会破坏机体γδT各亚型之间的比例平衡,导致Vδ2/Vδ1倒置。该综述阐述了γδT细胞免疫调控的特点以及HIV-1感染对Vδ2T细胞功能影响的研究进展

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