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-  2015 

血清microRNA作为乙型肝炎病毒相关肝细胞癌发生过程标志物的研究进展 Research Progress of Serum microRNAs as Biomarkers for HBV-Related Hepatocarcinogenesis

Keywords: 乙型肝炎病毒,乙型肝炎病毒相关肝细胞癌,慢性乙型肝炎,乙肝肝硬化,microRNA,血清,标志物

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Abstract:

微小RNA(microRNA,miRNA)是一类长度为21-25nt的非编码RNA,在正常细胞中参与调控细胞增殖、分化和凋亡等过程,近年研究发现它与肿瘤的发生发展密切相关。肝细胞癌(HCC)目前是全球范围内死亡率较高的癌症之一,研究提示血清microRNA有可能作为肝细胞癌的早期诊断标志物。本文综述了血清microRNA在乙型肝炎病毒(HBV)相关肝细胞癌(HBV-HCC)进展过程中的作用及其作为HBV-HCC早期诊断标志物的最新研究进展,为进一步深入研究奠定基础

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