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-  2018 

Narcotrend监测下右美托咪定在肾移植手术麻醉中的应用 Application of Dexmedetomidine in the Anesthesia of Renal Transplantation Under Narcotrend Monitoring

Keywords: Narcotrend监测,右美托咪定,肾移植

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Abstract:

目的:探讨Narcotrend(NT)监测下右美托咪定在肾移植手术麻醉中的应用。方法:选择肾移植手术患者40例,随机分为空白对照组(C组)和右美托咪定组(D组),D组麻醉诱导前10min泵注右美托咪定负荷量0.6μg/kg,随后泵注0.2μg/(kg·h)维持量至输尿管膀胱吻合完毕;C组泵注相同容量的生理盐水。两组病人均于负荷量泵注结束时静脉注射丙泊酚、舒芬太尼、顺苯磺酸阿曲库铵快速诱导;术中泵注丙泊酚和瑞芬太尼维持麻醉,根据Narcotrend监测调整丙泊酚速度,维持Narcotrend指数在27-64。分别记录两组:用药前(T0)、诱导即刻(T1)、插管成功后即刻(T2)、手术结束(T3)、麻醉苏醒拔管前(T4)的平均动脉压(MAP)、心率(HR);记录丙泊酚用量、瑞芬太尼用量、患者苏醒时间、苏醒期镇静躁动评分(SAS),术后24h、48h的血尿素氮(BUN)、尿量和预估肾小球滤过率(eGFR)。结果:T1、T2时D组的HR明显低于C组(P<0.05),但MAP差异无统计学意义(P>0.05);T0、T3时两组患者的HR、MAP差异无统计学意义(P>0.05);T4时D组的HR及MAP均明显低于C组(P<0.05);D组丙泊酚用量明显少于C组(P<0.05),两组患者瑞芬太尼用量和苏醒时间差异无统计学意义(P>0.05);D组SAS评分明显低于C组(P<0.05)。两组患者术后24h、48h的BUN、尿量和eGFR差异均无统计学意义(P>0.05)。结论:Narcotrend监测下右美托咪定可以维持肾移植手术患者平稳的血流动力学,减少丙泊酚用量,减少苏醒期的躁动,对术后短期肾功能无明显影响

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